BIOL 2021 Lecture Notes - Lecture 17: Glycogen Storage Disease, Pyruvate Carboxylase, Glycogen Phosphorylase

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9 Jul 2017
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Used when intracellular levels of glucose and atp are low. Muscle glycogen is fuel for muscle contraction. Liver glycogen is mostly converted to glucose for bloodstream transport to other tissues. Cleavage occurs by phosphorolysis cleavage of a bond by group transfer to an oxygen atom of phosphate. Glycogen synthesis elevated in patients. abdomen to protrude. Also affects gluconeogenesis: cori"s disease, deficiency in debranching enzyme, of all glycogen storage disease, affects both liver and muscle, muscle weakness and liver enlargement as a result of glycogen accumulating. Both mobilization (glycogen phosphorylase) and synthesis (glycogen synthase) of glycogen are regulated by hormones: insulin, glucagon, cortisol, and epinephrine regulate mammalian glycogen metabolism. Insulin stimulates the target organ/tissues to store and conserve fuel and decrease rate of fuel oxidation an anabolic. Hormone: glucose uptake of muscle and adipose tissue, insulin increases rate of glucose transport into muscle, adipose tissue via glut 4 transporter, insulin stimulates glycogen synthesis in the liver.

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