PS101 Lecture Notes - Lecture 13: Monoamine Oxidase, Dextroamphetamine, Codeine
Document Summary
Psychoactive drugs pervasive part of society today. Modify brain chemistry - cross blood-brain barrier. Decrease in responsivity to drug (need larger doses) Physiological reactions opposite to that of a drug. Compensatory responses after drug use is discontinued. Tolerance - over time you become more tolerant to drugs so you need more. Overdose often happens because people do drugs in a new environment; their body was not able to prepare because they didn"t recognize the different environment. Learning, anxiety regulation valium (diazepam, used to relieve anxiety, muscle spasms); ambien (zolpidem, used to treat insomnia) Ecstasy (mdma); lsd (hallucinogens); monoamine oxidase inhibitors (maois); selective serotonin reuptake inhibitors (ssris; antidepressants) Increases activity of gaba (inhibitory neurotransmitter - anxiety reduction) Decreases activity of glutamate (major excitatory neurotransmitter) Combination creates high" and then down" phase. Increases activity of norepinephrine, dopamine by blocking reuptake. Chronic use - cognitive impairment, brain damage. Continuous heavy use can produce amphetamine psychosis. Opium = product of poppy plant - opiates.
