PS101 Lecture Notes - Lecture 12: Agnosticism, Reuptake, Homeostasis
Document Summary
Take agnostic drugs (drugs that increase neurotransmitter activity: synthesis. Drug causes neuron to synthesize more transmitter molecules, store them more safely or release them: binding. Drug binds with receptor sites and activates it: reuptake. More transmitter molecules remain in synapse, available to activate receptor sites. Take antagonistic drugs (drugs that inhibit or decrease neurotransmitter activity: synthesis. Drug i(cid:373)pairs (cid:374)euro(cid:374)"s a(cid:271)ility to sy(cid:374)thesize, store or release tra(cid:374)s(cid:373)itter. Molecules may leak and degrade prematurely: binding. Drug binds with receptor site but is not similar enough for transmitter to activate site. Decrease in responsivity to drug (requires larger doses) Body attempts to maintain homeostasis: compensatory responses. Psychological reactions opposite to that of the drug. Brain is adjusting to body imbalance: withdrawal. Compensatory responses after drug use is discontinued: depressants. Moderate doses (reduce feelings of anxiety, produce euphoria) High doses (slow vital life processes, can be fatal) Increase in depressant = increase in gaba = decrease in cns.
