BI110 Lecture Notes - Lecture 17: Exergonic Reaction, Covalent Bond, Endergonic Reaction

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12 Dec 2017
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Atp hydrolysis: exergonic, spontaneous reaction, releases energy (negative delta g, delta g = -7. 3 kcal/mol. Enzyme-catalyzed reactions: enzymes bind to a reactant (substrate, enzymes are catalysts, they increase the rate of chemical reactions without themselves being consumed, highly specific, recognizing a unique substrate or a class of similar substrates, enzymes are proteins. Rate of a reaction: all reactions require an input energy, called activation energy (ea), to proceed, an enzyme accelerates the reaction by reducing ea, delta g is the same with and without and enzyme. Active site formation: the amino acids that form the active site are often far apart in the linear sequence of the unfolded enzyme, protein folding brings specific amino acids close to each other to form the active site. Inhibitors / activators: enzyme activity can be influenced by, inhibitors: decrease the activity of enzymes, reversible. Irreversible: activators: increase the activity of enzymes.

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