Physiology 3120 Lecture Notes - Lecture 9: Mechanotransduction, Asthma, Hyaline Cartilage
11 Aug 2016
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Document Summary
Ca is very important ion used in muscle contraction, nt release, co-factor for enzymes, etc. thus stored in bone due to easy access in case of ca shortage. Pth released from parathyroid glands flows in blood to kidney to increase ca reabsorption in distal convoluted tubule. Pth to bone to trigger ca release from bone store most ca from here. Vitamin d converted to calcitrol to increase ca absorption from food in gi tract. Endochondral ossification makes almost all (long) bones in body. Intramembranous ossification makes flat bones of skull: form cartilage template first and then bone formed on that template. Type ii collagen is fibrous provides resistance to pressure (no strength) Proteoglycans are highly glycosylated proteins (lots of sugar added) and bind tightly with water provides cushioning in later life for areas that retain cartilage. In this case, provides pathway for nutrients to travel as chondrocytes grow. Picture misleading as regular chondrocytes continuously proliferate to spread across entire template.
