Pharmacology 3620 Lecture Notes - Lecture 24: Pramipexole, Apomorphine, Dementia With Lewy Bodies

• School: Western University
• Department: Pharmacology
• Course: Pharmacology 3620
• Professor: Rommel Tirona

Document Summary

Parkinson"s disease: first described by dr. james parkinson in 1817, chronic, progressive, neurodegenerative disease. Is the second most common neurodegenerative disorder, after alzheimer disease. Intracytoplasmic inclusions (lewy bodies) in the remaining, intact nigral neurons: loss of dopaminergic neurons in the substantia nigra. Pathological markers: motor symptoms are related to this, brain plasticity, so would need to lose about 80% of the dopaminergic neurons in. Sn to start showing the symptoms enough to be diagnosed: thus, when you"re diagnosed, already a large amount of the dopaminergic neurons have died, synuclein, which forms the major pathological hallmark, has a characteristic way of. Synuclein spread spreading: probably involves peripheral spreading in the ans, in the gi, etc, via vagus nerve get the autonomic disturbances because of spreading of the misfolded protein. In pd, there is a lack of da neurons: they found that the pathology of the lewy body that is found in the brain of those with.