Pathology 3500 Lecture Notes - Lecture 40: Metabolic Bone Disease, Osteomalacia, Osteopenia
1 May 2018
School
Department
Course
Professor
Rickets and Osteomalacia
● Rickets: children, osteomalacia: adults
● Decrease or failure of minzation of bone
○ Show up as decrease bone density on an x-ray thi is osteopenia)
● Main cause is Inadequate vitamin D
○ Dietary insufficiency
○ Liver disease and kidney disease
■ Metabolic process in the liver and kidney are needed to produce vitamin
D
● No vitamine D -> no calcium -> can’t mineralize bone
● Lead to weak bone that are prone to fractures
○ Repetitive fractures and healing over time lead to deformity (bowing of the long
bones) and weakness
● Some other conditions
○ Microfractures and gravity
● Treatment
○ Adequate diet (vitamin D supplement)
● Microscopic view
○ Non-mineralized bone
■ Has a slight lighter area on top of mineralized bone
● “Seam” of non-mineralized bone
■ Bone is being laid down but there is a lag in mineralization
● Should not be seen
Paget’s Disease of the bbone
● Osteoblast and osteoclast are not in balance
● Metabolic bone disease
● Initial excessive osteoclastic activity
○ Bone lysis
○ initial excessive osteoclastic activity
○ balanced osteoclast/osteoblast differ diffuse oster
● Slow down ostoclas from pi
Osteoporosis
● Lots of high fractures in older patients
○ Low forae imoant a
● Higher risk of mortalityes rate post fractire
● Ex- e
Dont have a good treaming program
● Deadted late
find more resources at oneclass.com
find more resources at oneclass.com
Document Summary
Show up as decrease bone density on an x-ray thi is osteopenia) Decrease or failure of minzation of bone. Metabolic process in the liver and kidney are needed to produce vitamin. No vitamine d -> no calcium -> can"t mineralize bone. Lead to weak bone that are prone to fractures. Repetitive fractures and healing over time lead to deformity (bowing of the long bones) and weakness. Has a slight lighter area on top of mineralized bone. Bone is being laid down but there is a lag in mineralization. Osteoblast and osteoclast are not in balance. Balanced osteoclast/osteoblast differ diffuse oster initial excessive osteoclastic activity. Lots of high fractures in older patients. Higher risk of mortalityes rate post fractire. Men tend to have more bone denosty than female. Pjsical take a look at each individual to see if they have cardiovacular risk. Baed on uderstarning of celular events of bone. More common diseae that affect young idividiuals (teens)
