Pathology 2420A Lecture Notes - Lecture 6: Oncotic Pressure, Extracellular Fluid, Hydrostatics

• School: Western University
• Department: Pathology
• Course: Pathology 2420A
• Professor: Candace Gibson

Document Summary

These molecules include the plasma proteins; albumin is responsible for most of the osmotic pressure since it is the most abundant plasma protein. A thrombus is an aggregation of blood factors, primarily platelets and fibrin with entrapment of cellular elements, frequently causing vascular obstruction at the point of its formation. Survival of cells and tissues is dependent on the oxygen and nutrients provided in the blood supply as well as on a normal fluid balance. 60% of a persons body weight is water 40% intracellular, 15% interstitial, 5% plasma. Derangements in either blood supply or fluid balance cause edema, thrombosis, embolism, ischemia and infarction, altered perfusion. Movement of fluid between vessels and tissue is governed by the balance between 4 forces: hydrostatic pressure in vessels which measures 32mmhg at arterial end and. Edema: leading to swelling of the subcutaneous tissues. Accumulation of abnormal/excess fluids in the interstitial/intercellular tissue.