Pathology 2420A Lecture Notes - Lecture 7: Lymphedema, Osmosis, Cerebral Infarction
23 Mar 2018
School
Department
Course
Professor
Document Summary
These molecules include the plasma proteins; albumin is responsible for most of the osmotic pressure since it is the most abundant plasma protein. A thrombus is an aggregation of blood factors, primarily platelets and fibrin with entrapment of cellular elements, frequently causing vascular obstruction at the point of its formation. Introduction: survival of cells and tissues is dependent on the oxygen and nutrients provided in the blood supply as well as on a normal fluid balance. Edema: definition: accumulation of abnormal/excess fluids in the interstitial / intercellular tissue -- > leading to swelling of the subcutaneous tissues. Normal fluid control mechanism depends on: starling"s law, local factors lymphatic obstruction, vascular permeability, systemic factors, cardiovascular function, overall fluid balance, salt retention. Interstitial fluid pressure (tissue tension) = 3-4 mmhg: tissue (interstitial) fluid osmotic pressure (very low). Edema will occur when there is: an increase in intravascular hydrostatic pressure, a fall in colloid osmotic pressure/oncotic pressure of plasma.
