Microbiology and Immunology 3820A Lecture Notes - Lecture 2: Toxic Shock Syndrome, Coagulase, Fibronectin

• School: Western University
• Department: Microbiology and Immunology
• Course: Microbiology and Immunology 3820A
• Professor: David Colby

Document Summary

Identify by colonial and gram stain morphology: coagulase positive. Staphylococcus aureus virulence factors: cell wall virulence factors: ability to cause disease, protein a which binds to the fc portion of igg and inhibits phagocytosis, fibronectin-bind protein (fnbp) old name= cold soluble globulin (glob= old word for protein) Almost any normal protein precipitate in cold and dissolves in heat. Binds to the same site as gram negative. Now we know we produce fibronectin to coat mucosal surfaces/respiratory tract thereby stop gram negative from coating same surfaces in large numbers. Mostly what we have is gram positive coating our surface. Staph aureus has adaptation for protein to bind to fibronectin itself. Impossible to stop it from binding to us: has other adaptatio(cid:374) to (cid:271)i(cid:374)d to fi(cid:271)ro(cid:374)e(cid:272)ti(cid:374) + it"s a gra(cid:373) positi(cid:448)e, has tenacious grip on mucosal surfaces. People in hospital have same normal flora.