Microbiology and Immunology 2500A/B Lecture Notes - Blastomycosis, Histoplasmosis, Sporotrichosis
16 Oct 2012
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Document Summary
Laboratories without biological safety cabinets must not work on any mold, except those believed to be dermatophytes. There are several identification criteria: growth rate in culture, presence of a yeast phase (is it dimorphic?, colonial and microscopic morphology (most important, biochemical tests. Examination of the hyphae enables classification into 3 groups: septate unpigmented hyphae (hyaline). Includes the majority of medically important molds: septate brown pigmented hyphae (dematiaceous, aseptate wide hyphae, characteristic of the lower fungi mucorales. Invasive infections in severely immunocompromised patients, especially with prolonged neutropenia. Cause chronic sinusitis and aspergilloma (fungus ball in preexisting pulmonary cavity) in immunocompetent patients. Tissue biopsy need silver stain to differentiate fungal elements. Repeated branching, but eventually end up going in the same direction (same behaviour as schooling fish) Rapidly growing greenish colony which you often see on moldy bread. Trichophyton spp. (red colony makes it easy to identify) Dark, moist conditions to get athlete"s foot.
