Microbiology and Immunology 2500A/B Lecture Notes - Lecture 25: Green Fluorescent Protein, Multinucleate, Measles Virus
20 Feb 2017
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Document Summary
Understanding the basics of an infection cycle and virological methods utilized to study it. Lab hosts utilized to study infectious cycle. How to asses infectious cycle: cytopathic effects. It orchestrates synthesis of all required elements: attachment virus binds to receptor on outside of cell and enters. Something on the outside of virus recognizes something on the outside of the host cell that allows very specific attachment to occur. Once this recognition occurs, virus uses cell biology to enter. Virions are vehicles to infect the next host. Virus is only infectious before it enters host cell & upon. In most of these steps, the virus itself is not infectious. Ebola virion recognizes something on host cell surface. Enters host cell and eventually loses shell to expose viral genome. Host ribosomal machinery used to make de novo proteins. Viruses assembled and able to bud and infect the next host.
