Microbiology and Immunology 2500A/B Lecture Notes - Lecture 8: Sepsis, Pathogenic Bacteria, Pathogen-Associated Molecular Pattern

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Learning objectives: describe the steps involved in phagocytosis, explain how neutrophils, macrophages, immature dendritic cells and natural killer cells are important for innate immune defense. Bacteria are living cells that have dna and can reproduce on their own. Cannot penetrate through a cell membrane due to their size. Viruses are small particles that must replicate inside a living host cell. Only has genetic material (viral dna or rna) Replication = uses host cell"s metabolic machinery to synthesize and assemble viral components into new virus particles. All viruses have both extracellular and intracellular phases. Start as an extracellular virus and then enters into host cell (intracellular virus) New virus particles will then exit the cell and will become an extracellular virus. Pay attention on exam: if the virus is intracellular or extracellular. If epithelial cells barrier is permeated innate cells activated. Different immune defenses are used against extracellular v. s. intracellular pathogens based on where a pathogen resides and/or replicates.

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