Microbiology and Immunology 2500A/B Lecture Notes - Lecture 3: Cytostome, Phagolysosome, Neutrophil

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Explain how neutrophils, macrophages, immature dendritic cells and natural killer cells are important for innate immune defense. Different immune defenses are used against extracellular vs. intracellular pathogens. Based on where a pathogen resides and/or replicates. Pathogen living or replicating outside host cell. Pathogen living or replicating inside host cell. Cannot penetrate cell membrane due to their larger size. Some have both extracellular and intracellular phases. Most are extracellular- large so they live and replicated outside cell. Must be inside living host cell to replicate. Use host metabolic machinery to make/assemble viral components into new viruses. All viruses have both extracellular and intracellular phases. Extracellular: in the air/environment not in a cell. Intracellular: once it enters a host cell and replicates. If epithelial cell barrier is permeated innate cells are activated. Internalizes it into a phagosome (internal vesicle) Kills pathogen when the lysosome releases it contents. Lysosome contains acids and enzymes that quickly kill most ingested pathogens.

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