Microbiology and Immunology 2500A/B Lecture Notes - Lecture 5: Bone Marrow, Blood Type, Lymphoblast

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Main defenses in adaptive immunity: b cells immunity important against extracellular pathogens, antibodies, t cell immunity important against intracellular pathogens, helper t cells (th cells; cd4+ t cells, cytotoxic t cells (ctl; cd8+ t cells) Induction of adaptive response adaptive immune response immunological memory. Cells turn into effector cells to destroy pathogen. Re-exposing self to a similar pathogen will have a much faster and greater effect since memory cells have developed from previous exposure: note: innate immunity works concurrently with adaptive immunity! First exposure to pathogen = primary response: na ve b and t cells develop into effector cells and memory cells. Subsequent exposures to identical pathogen = memory response: memory cells respond to pathogen more effective! Important features of adaptive immunity are memory and specificity. In a study of smallpox, the amount of memory cells do not decrease for 15 years. From hematopoiesis lymphoid progenitor cell depends on b or t next.

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