Biology 1001A Lecture Notes - Lecture 6: Copy-Number Variation, Single-Nucleotide Polymorphism, Endogenous Retrovirus
17 Feb 2017
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Document Summary
Amount of dna is very different in different organisms and even the same species. Variation means mutation: what is a mutation, mutations are a change in the double stranded dna sequence, anything that is not a double stranded change is just damage, not a mutation. Vast majority of variants are snps (single nucleotide polymorphism ) About 2500 structural variations including mobile elements, cnv (copy number variation), inversions, etc. About 100 variants are de novo (only found in them) Bacterial elements code for there own mobility (transposase) Transposon-can move between themselves and can even move the genes in between them. Some elements move with, some without, making a copy. Some move by cut and paste (remove themselves and go somewhere else), others are copy paste (remain where they were and appear somewhere else: retrotransposons move via rna, move by reverse transcriptase, retroviruses can move within genomes. Enters your genome and then mutates so that it cannot exit.
