Biology 2581B Lecture Notes - Lecture 16: Transfer Rna, Comefrom, Penetrance
23 Apr 2016
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Lecture 16: more on encode & genetic modifications. There are many copies of a regulatory element, but they are still only a small proportion. Removing it cause major loss of fitness or death. Encode: goal was to uncover all the functional elements in the human genome, particular those outside of genes. 75% of the human genome is transcriptionally active. At some point 75% of the genome is going to be converted to rna. No e(cid:448)ery cell, tissue, life cycle point is transcriptionally acti(cid:448)e . Only (cid:449)hen you look across the big picture. 80% of human genome is associated with at least one biochemical function! 95% of the genome lies within 8kb of a dna protein interaction (as assayed by bound. 99% is within 1. 7kb of at least one of the biochemical events measured by encode. 8. 5% of genome involved in transcription factor binding. Transcription factors: dna binding proteins that regulate gene expression.
