Biology 2581B Lecture Notes - Lecture 16: Dinoflagellate, Arginine, Epigenetics
14 Apr 2016
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Document Summary
Human genome was sequenced in 2000 and found to be 98% non-coding. Collins said they"re there you just can"t see them hype for non- coding dna being functional. Doolittle was on the pro-junk dna team. Uncover all functional elements of the human genome, particularly for non- coding regions what proportion of non-coding dna is functional. 75% of the human genome is transcriptionally active (converted to rna) Not in every tissue all the time; it"s across development and tissues. 8. 5% is involved in transcription factor binding (regulatory elements) Thousands of regulatory sites (400,000 transcriptional enhancers, 80% is associated with at least 1 biochemical function says most of genome is functional. Junk dna debate: hinged on the definition of function . Eg. consider replication to be a biochemical function then 100% of genome is functional . Lots of transcriptional noise regions get transcribed for no good reason (not translated, functional rna, or regulatory regions)
