Biochemistry 2288A Lecture Notes - Coiled Coil, Globular Protein, Enzyme Catalysis
20 Nov 2012
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1-6, 11-22, 26-35: central dogma, amino acids, protein structure, protein function, enzyme catalysis, protein purification. Enzymes tend to be globular fibrous proteins: simply elongated 3d shape (for proteins that need to span a long distance) ex. a-keratin: extremely stable long-lived found in hair, nail, horn. Common outside the cell - part of the extracellular matrix that binds cells together to form tissues proteins are flexible. Results in changes in the position of structural domains. Can be caused by environmental changes, binding of different molecules, etc. Crucial for the function of motor proteins, sensory proteins, etc proteins can come in a huge variety of shapes and electronic topography (arrangement of polarity on the protein) > due to variety of amino acid side chain properties and tertiary folding patterns. > therefore allows for extreme specificity when binding to molecules. A small area of the protein surface will be complementary to the structure of the molecule.
