Biochemistry 2280A Lecture Notes - Lecture 12: Blood Sugar, Glycogen, Hmg-Coa Reductase

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Topic 12: fatty acids, ketone bodies, and biosynthesis. Adipocyte (fat cells) triacylglycerols function as a form of energy storage which can be utilized when needed. Atp, and are stored as triacylglycerols in adipocytes. **reductive process*: palmitate (16c fatty acid) is the main product, 8 acetyl-coa + 14 nadph + 7 atp palmitate + 8 coa + 14 nadp+ + 7adp/pi. Ketone bodies: small molecules made in the liver from the breakdown of acetyl-coa, which can cross the blood-brain barrier (the (cid:271)rai(cid:374) (cid:272)a(cid:374)"t use energy from fatty acids directly but can in this way) In the unfed state, fatty acid oxidation is the major energy source in muscles and liver. Even though ketone body production increases in the first few days of the unfed state, ketone bodies are not the main source of energy for the brain during this period. All carbons of cholesterol are from acetyl-coa. Acetyl-coa hmg-coa (hmg-coa reductase) mevalonate cholesterol.

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