Biochemistry 2280A Lecture Notes - Lecture 11: Fumaric Acid, Rotational Energy, Glycolysis
13 Feb 2017
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Coenzyme = organic cofactor, often a rxn substrate (could change during rxn) Prosthetic group = tightly bound cofactor carriers (basically permanent part of enzyme) Electrons from nadh fadh2 are transferred through electron acceptors in the chain to make water at the end. Nad+ fad goes to citric acid cycle again. Point is to move protons from matrix to intermembrane space to create potential energy. Oxygen has the highest affinity for electrons hence why it"s at the end. Electron carriers (lowest to highest affinity, order not absolute) Each copper can accept an electron (cu2+ cu+) 4 electrons needed to reduce oxygen to two waters. Binding site for nadh must be in matrix. All the carriers beside ubiquinone are tightly bound to a protein. After electrons get transferred to q to make qh2. 4 protons come in 8 protons go out and. Cyanide binds to oxygen binding site, they cant complete electron transport, cant do citric acid cycle, cant produce atp.
