Biochemistry 2280A Lecture Notes - Lecture 6: Myosin Light-Chain Kinase, Histone Deacetylase, Reaction Coordinate
28 Oct 2016
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Document Summary
Biological catalysts: perform nearly all chemical transformations in cells, accelerate but are unchanged by a reaction. Too slow without enzymes: regenerated in identical form after a cycle. Name most often ends in (cid:494)ase(cid:495), (cid:494)in(cid:495) or (cid:494)zyme(cid:495) Substrate: the molecule on which an enzyme acts. Specificity: many enzymes will recognize only one or a few of the hundreds of thousands of kinds of molecules in the cell. Rapidity: enzymes can accelerate reactions by billions or trillions of times over the rate of uncatalyzed reactions. Ability to work under mild conditions: low temperature (e. g. 37 c) and pressure, neutral ph, everything is in water, aqueous environment. Regenerated in original form when reaction is complete. Active site: part of the enzyme where the reaction is and where the substrate binds and is transformed into the produce. Substrate binds in active site: multiple weak bonds, binding is reversible.
