HLTH 251 Lecture 5: Sex Hormones and Sexual Differentiation 18 Jan 2016

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Hormones: chemical substance secreted by the endocrine glands into the bloodstream. Testosterone (androgen): secreted by the testes, ovaries, and adrenal glands. Progesterone: secreted by the ovaries and adrenal glands. Gnrh (gonadotropin-releasing hormone): secreted by the hypothalamus; stimulates production of fsh and lh in the pituitary. Fsh (follicle-stimulating hormone): controls sperm production and ovum follicle development: helps with sperm production and testosterone production, helps with follicular development. Lh (luteinizing hormone): controls testosterone production and ovulation: helps with testosterone production, helps with estrogen secretion. Inhibin: secreted by the testes and ovaries to suppress fsh production. Differentiation occurs during the seventh to tenth week after conception: presence of the sex-determining region (sry), y chromosome, sry is key, tdf (testis-determining factor) production caused by the sry, leads to testes development. In the absence of tdf and presence of ovaries: Mullerian ducts develop into fallopian tubes, uterus and upper part of the vagina. Wolffian ducts develop into epididymis, vas deferens and ejaculatory duct.

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