PSL301H1 Lecture Notes - Lecture 11: Deep Vein Thrombosis, Peripheral Artery Disease, Rheumatic Fever

• School: UTSG
• Department: Physiology
• Course: PSL301H1
• Professor: French, Gramolini, Richardson, Wong

Document Summary

Cardiovascular disease primarily include: coronary heart disease, cerebruvascular disease, peripheral arterial disease, rheumatic heart disease (streptococcal bacteria, congenital heart disease, deep vein thrombosis and pulmonary embolism. Cardiovascular disease is the leading cause of death worldwide. Cardiovascular disease is mostly due to problems in circulation of lipids: elevated blood lipids. Leads to atherosclerosis: diabetes mellitus one of the major risk factors for developing cvd. Fats broken down into fatty acids and dumped into blood. Stable plaques have thick fibrous caps that separates the lipid core from blood. Vulnerable plaques have thin fibrous caps that are more likely to rupture, exposing collagen and activating platelets that initiate a blood clot (thrombus) The clot can dislodge, and circulate (thromboembolism) If the clot blocks flow to the heart muscle, a myocardial infarction (heart attack) results. Coronary heart disease: coronary heart disease/ischemic heart disease a form of cv in which the coronary arteries become blocked by cholesterol deposits (plaques) and blood clots.