PCL102H1 Lecture Notes - Lecture 2: New Drug Application, Lead Compound, Drug Discovery
31 Jan 2019
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Unmet medical need: a condition whose treatment or diagnosis is not addressed adequately by available therapy (e. g. many neurological disorders) Includes: an immediate need for a defined population (e. g. , to treat a serious condition with no or limited treatment) and a longer-term need for society. The types of drugs under development are mostly for cancer and neurology then cardiovascular > diabetes. 31% of a drug approved (as of 2015) are oncology drugs, next is infectious disease, metabolism and endocrinology, and gastroenterology. First-in-class = a new drug target thus a new way to tackle disease. Me-too drug is when a drug already exists to treat the disease by addressing the same target: the me-too drug might show novel chemistry. In addition, there are finical aspects to drug development (e. g. patent protection before a drug becomes generic is 20 years: canada spends about /person/year on pharmaceuticals. Medical need (i. e. is the condition life-threatening)
