PCL200H1 Lecture Notes - Lecture 4: Μ-Opioid Receptor, Rheumatoid Arthritis, Periaqueductal Gray
12 Dec 2019
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Injury: surgical pain, cancer, headaches and migraine, chronic/neuropathic pain, neuropathic pain - no evidence of tissue damage, where people become addicted to opioids. Classes of pain medicines local anesthetics: nsaids and acetaminophen, opioids, opiates are derived from poppy (morphine, heroin, opium, opioids are drugs that activate the mu opioid receptor do not come from poppy plant - opioids. Ibuprofen, naproxen, aspirin, diclofenac: bene ts: reduce pain, redness, swelling, fever. How it works pain starts sends signal starts in spinal cord, ascending pathway. Rst place is goes is thalamus - place that receives info sensory cortex - recognition something painful has happened. Limbic cortex - unpleasant, aversive stimulus frontal cortex : descending pathway - originates in pag (periaqueductal grey) brain can decide to suppress painful sensations. Prostaglandins: prostaglandins released whenever you have tissue damage (redness, swelling, pain, facilitate ring of pain sensors and ascending pathway, block action of enzyme that creates sensation of pain.
