IMM250H1 Lecture Notes - Lecture 2: Lymphopoiesis, Innate Immune System, Thymus
Document Summary
Innate immunity never changes (ie. never gets better) when the same pathogen comes back; in contrast, the adaptive immunity can get better. Cytokines wide range of small, soluble molecules that modify the behaviour of leukocytes in many ways. Secreted by innate and adaptive leukocytes (and some non-hematopoietic cells) Organisms so small that they can"t be seen with the naked eye; goal of microbes is to replicate. The microbes that colonize body surfaces; normally harmless or even beneficial. Small subset of microbes that cause disease. Lymphocytes - immune cells responsible for adaptive immunity. Bone marrow common lymphoid progenitor cells. Some mature in the bone marrow and become mature b cells. Receptor 4 protein structure (2 light chains, 2 heavy chains); variable region (for recognition) and constant region (for response); has two antigen binding sites; called an antibody when secreted. Recognition recognizes its antigen on its own. Others travel to the thymus and develop into mature t cells.
