IMM250H1 Lecture Notes - Lecture 2: Adaptive Immune System, Herd Immunity, Clonal Selection
Document Summary
2 lecture 2 - features of the adaptive immune response. Overview of innate and adaptive immune responses. How b and t cells recognize and respond to host threats. Case study: jenner"s legacy the eradication of smallpox. Changes in their balance can affect health. Inherent ability to cross anatomical barriers and breach innate host defenses. Cause disease in healthy person with normal immune defenses. Exist outside host but sometimes invate and grow in extracellular. Innate - leukocytes have prrs recognize pamp + damp. Adaptive: lymphocytes have receptor that recognize antigens. Primary: where immature lymphoid mature b and t. Secondary: where mature lymphocytes activated by antigen. Bcr, tcr on a given lymphocyte is identical & unique to htat lymphocyte. Antigens can be derived from anything (pathogen and non-pathogen) Human genome around 25k genes, but 100kk pcr,tcr. Vdj segments in germline bcr, tcr; random vdj choice (note: no d in bcr light chain or tcr a chain)
