IMM250H1 Lecture Notes - Lecture 3: Zymogen, Respiratory Burst, Neutrophil Extracellular Traps
Document Summary
Ligand binds, thus the receptor can bind to an adapter protein, more signalling processes follow, many of which involving kinases. Ikb and translocation of nfkb to the nucleus, to bind to the regulatory elements to change the behavior of the cell. Innate immunity: the first line of defense to infection part ii: cellular and humoral mediators of innate defense. Soluble mediators of innate immunity: cytokines, complement, communication that can tell cells to change their behaviour. In the serum that helps to fight against infection. Pathoge(cid:374) (cid:271)(cid:396)ea(cid:272)hes (cid:271)a(cid:396)(cid:396)ie(cid:396) a(cid:374)d the(cid:374) : releases pamps. Like lps, flagellum: detected by prr, activates signal transduction, activates nf b, controls the production of soluble mediators of innate immunity (among other things!, to fight that particular infection. What are cytokines: cytokine: a category of signaling molecules that are used in cellular communication, mediate (cid:862)inflammation(cid:863) a(cid:374)d ge(cid:374)e(cid:396)all(cid:455) e(cid:374)ha(cid:374)(cid:272)e the a(cid:271)ilit(cid:455) of ou(cid:396) (cid:272)ells to get rid of an invading pathogen and promote healing.
