BIOC39H3 Lecture Notes - Lecture 5: Acute-Phase Protein, Mannose Receptor, Tlr3

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18 Nov 2016
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Gram- positive is that is has a thick peptidoglycan layer and a gram- negative bacteria has a thin peptidoglycan layer and an outer membrane. Both of these categories of bacteria have conserved molecular features of. Mannose receptor has multiple crds and dectin-1 has a single carbohydrate recognition domain: so they will recognize mannose and beta glucans on the surface of pathogens. Complement receptors bind to ic3b as well as other microbial products. These receptors cluster at the cell surface. When they are engaged, multiple receptors are engaged simultaneously. Lps is on the surface of graham negative bacteria. Scavenger receptors bind to negatively charged ligands. Cd(cid:885)(cid:888) binds phosphatidylserine this is important for macrophages to phagocytose apoptotic cells. Variety of different phagocytic receptors, each binding to different microbial features that are common not to a single type of bacteria but to multiple types of bacteria. They are common across the eukaryotic kingdom. Are a large family of signaling prrs.

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