BIOC39H3 Lecture Notes - Lecture 4: Immunoglobulin Heavy Chain, Monoclonal Antibody, Innate Immune System
4 Mar 2020
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Document Summary
Lecture 4 antibody structure and generation of ig (immunoglobulin) diversity. Agenda: today"s lecture kicks off a series of five lectures based on adaptive immunity. Structure of an antibody: ig domain and hypervariable regions, antibody isotypes, epitopes what they are and how they are recognized, affinity vs avidity, good antigens make strong antibodies. Immunologist"s toolbox: monoclonal antibodies, early hypotheses for ig diversity. Recognition mechanisms of innate vs adaptive immune system. Adaptive immune system: recognize conserved pamps or altered self (context of. Nk cells: cell surface receptors of a single molecular type (ex. B and t cells have the same type across all cells: fixed repertoire of cell, almost infinite repertoire surface and soluble molecules (ex. Toll-like and cytoplasmic receptors) (specificity: receptors are germline, receptors are somatically encoded (inherited in the. Dna from one generation to the next) encoded (occur in a single body cell and cannot be inherited)
