HMB265H1 Lecture Notes - Lecture 15: Meiosis, Frameshift Mutation, Northern Blot
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Mutation- is the process whereby genes change from one allelic form to another. The creation of entirely new alleles can occur. Mutations can appear spontaneously on genes at any time in the organism or may be induced by a mutagen. Only mutations that took place on the germ line cells can be transmitted to the progeny, not somatic cells. Substitution- base is replaced by one of the other 3 bases. Deletion- block of one of more nucleotide (base) pairs is lost. Insertion- block of one of more nucleotide (base) pairs is added. Inversion- 180* rotation of a segment of dna. Chop, turn the sequence 180 degrees and ligate it back into dna sequence. Reciprocal translocation- parts of 2 nonhomologous chromosomes change places. Note: if it was a crossing over of homologous chromosomes, this would be known as recombination** Transition-a g (purine purine) (atgc) Transversion- a c (purine pyrimidine) (t g)
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