CSB328H1 Lecture 6: Lecture 6
17 Oct 2017
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Marginal zone: induces the mesoderm = conditional specification: vegt nodal-related proteins mesoderm induction. Forms the endoderm which later on gives rise to the gut. Sox17 endoderm specification = autonomous specification: vegt determines the fate. Movement of vegetal cells are important for gastrulation. Strong tgf signaling from the nieuwkoop centre induction of dorsal mesoderm: nieuwkoop centre: vegt + -catenin. Neuroectoderm is induced by the underlying dorsal mesoderm. Heterotopic transplantation of the dorsal lip into the region that normally develops into ventral epidermis. Different newt species have different pigmentation of eggs. She took one early gastrula embryo out of each newt and put the pigmented embryo in the no pigmented newt. All cells are competent to respond to bmp. Bmp induces ventral fates: ventral ectoderm epidermis, ventral mesoderm blood vessels, ventral endoderm, the whole embryo induces ventral fates because they all respond, therefore we need inhibitors so this does not occur.
