BCH210H1 Lecture Notes - Lecture 5: Membrane Transport, Pancreatic Ribonuclease, Cyclic Adenosine Monophosphate

• School: UTSG
• Department: Biochemistry
• Course: BCH210H1
• Professor: Stavroula Andreopoulos

Document Summary

Lecture 5 outline: structural proteins in cells, globular proteins, membrane proteins, protein data base (pdb) Pdb can be accessed to look at all the proteins" 3d structures and properties. Fibres inside cells: actin, microfilaments, make up cytoskeleton inside cell. Fibres inside cells are long polymers made up of subunits: actin in every cell in the body, including erythrocytes (cytoskeleton gives disc-like shape) Filaments all composed of different types of subunits, contributing to the cytoskeleton: actin filaments (green circles are actin monomers single polypeptide, that can polymerize from g-actin to f-actin, filamentous) Important for giving cells their shape, allowing movement (e. g. , lymphocytes) Proteins fold up to attain globular 3d structures, which can then assemble into quaternary state, which can be very long. The chain between actin and f-actin is regulated by atp. If you depolymerize actin, you can break the filament, and stop movement and transport along the filament (i. e. , nerve transmission: higher order structures are functional part of the protein.