BIO230H1 Lecture Notes - Lecture 7: Aconitase, Protein Aggregation, Antisense Rna
31 Jan 2018
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BIO230H1 Full Course Notes
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Thursday, september 28th, 2017 1pm-2pm (alberts et al. Lecture 7 outline: translational regulation, post-translational regulation. From rna stability and processing to the process of translation. Translation is the process of producing protein from rna, carried out by ribosomes. Even if an rna makes into the cytosol, is properly processed and stable, it doesn"t mean it will be automatically translated there are many translational regulatory mechanisms. Regulation of the proteome: differences in the proteins expressed by two human tissues, red: common to both, blue: tissue specific. Translational regulation: both prokaryotes and eukaryotes use translational control mechanisms to regulate protein expression often in response to stressful situations, such as low nutrients, infection, or environmental stresses (e. g. , temperature) Prokaryotes: mrnas have a six nucleotide shine- Aug start codon: correctly positions aug in the ribosome and provides translational control mechanisms, you want an immediate response to environmental conditions stopping translation is better than transcription in this case.
