BIO130H1 Lecture Notes - Lecture 11: Adherens Junction, Tight Junction, Basal Lamina
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BIO130H1 Full Course Notes
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Week 5 interactions between cells and their environment. 2 main ways that cells are organized into tissues: epithelial cells in surface. Ex: dermis = connective tissue that underlies epidermis. 2 organizations very different: epithelial tissue has a lot of cells and cells are directly in contact with each other. Connection of cytoskeleton of one cell to that of another through cell junctions gives epithelial sheet strength: under epithelial tissue have basal lamina/basement membrane. Thin layer of extracellular matrix = basement membrane. Cells in epithelial layer joined to basement membrane and to each other: underlying connective tissue (dermis) In this example, cells are mostly fibroblasts which are tightly joined to extracellular matrix. Extracellular matrix supports tissue in this case: extracellular matrix in both cases is formed by sugars and proteins secreted by cells in the tissue. But ecm of connective tissue diff from organisation of basal lamina. Intestinal lining, skin epidermis: cells closely associated, cytoskeletal filaments provide resistance.
