BIO130H1 Lecture Notes - Lecture 11: Atp-Binding Cassette Transporter, Extracellular Fluid, Mitochondrion
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BIO130H1 Full Course Notes
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Some cells have a round shape, but polarized cell has distinct functions on different sides of the cell. May be contradictory with membrane proteins (move freely in lipid bilayer) In fact there are special proteins at those junctions that prevent protein mixing. Transcellular transport of glucose requires the asymmetric distribution of membrane proteins. Tight junction prevents proteins on apical membrane to mix with those on the basal plasma membrane: basal membrane connected to basal lamina to. Intestinal epithelial cells transport proteins and is restricted by tight junctions. On the apical membrane there is na+/glucose symporter. Basolateral plasma membrane glut2 uniporter and na+ /k+ pump: work together to transport glucose through the membrane. Intestinal epithelial cells will be unable to import glucose from the intestinal lumen: the na+/k+ pump on the basalolateral domain of the intestinal epithelial cells will not function, glucose symporters will be disrupted. F-type functions in one mode; v-type functions in the other direction.