BIO130H1 Lecture Notes - Lecture 5: Proofreading, Bind, Disulfide
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BIO130H1 Full Course Notes
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Low mutation rates are necessary for life as we know it. Cells of sexually producing organisms have two types: germ cells and somatic cells. Germ cells transmit information from mother to daughter cells: must be protected against high rates of mutation. Somatic cells must also be protected: may lead to cancer if not. Bacterial chromosomes have a single origin of dna replication (typically) In e. coli, an origin of replication that has just been used is blocked by newly synthesized a nucleotides to carefully regulate this synthesis when sufficient nutrients are available: further initiation continues only when as are methylated. Replication origins activated in clusters (replication units) Replication forks formed in pairs, create replication bubble as they move in opposite directions, stopping only when they collide. Dna replication takes place during only dna synthesis phase of cell cycle. Create 2 complete copies that are joined until mitosis.
