NROB60H3 Lecture Notes - Lecture 10: Substantia Nigra, Dyskinesia, Putamen
13 Sep 2016
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Cerebellum: what functions are involved, examination of cytoarchitecture and key pathways. Hindbrain: pons, cerebellum, medulla oblongata, spinal cord. Compares: what you thought you were going to do (according to motor cortex, with what is actually occurring in limbs (according to proprioceptive feedback, and corrects movement if problem exists. Works ipsilaterally: same side of cerebellum. Once master new skill (e. g. riding a bike: it becomes imbedded in cerebellum. Hippocampus on the other hand is not. Allows for coordinated movements (e. g. balance) of muscles and joints by synthesizing data from: brain stem, spinal cord, cerebral cortex, sensory info from muscles. Two main theories: regulator of the timing of movements, learning machine / encoding info. Marr-albus model of motor learning: simple synaptic plasticity mechanism involving ltd of parallel fiber synapse. Predicts plasticity of the parallel fiber synapse if it is active at the same time as the climbing fiber input to the postsynaptic purkinge cell. Long term depression (vs ltp long term potentiation)
