BIOC65H3 Lecture Notes - Lecture 3: Chronotropic, Paraxanthine, Xanthine
12 Dec 2017
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Lecture 3: lessons from coffee and tea pharmacological effects of caffeine and catechins: Neurology, vasculature, sugar & fat metabolism; introduction to inflammation. Ld50: 0. 19 (g/kg: para(cid:272)elsus: (cid:862)dosis fa(cid:272)it (cid:448)e(cid:374)e(cid:373)u(cid:373)(cid:863) (cid:862) i(cid:373)ilia si(cid:373)ili(cid:271)us sol(cid:448)u(cid:374)tur(cid:863) i(cid:373)ilar thi(cid:374)gs are dissol(cid:448)ed (cid:271)y similar things and are attracted to similar things. If the chemical is naturally occurring in the body, it would most likely have the same/similar effect: could either act as an agonist or antagonist. Coffee: sometimes, even the smell of grinding coffee has effects from head-to-toe already, caffeine is an adenosine antagonist. Pharmacologically, caffeine affects this more - # of beats/min can be affected by this as well: adenosine tired 2-4x higher conc. Indirectly increase glucose levels gluconeogenesis production of new glucose: more natural way, we breakdown glycogen pool from muscles and fat, glycolysis is blocked by caffeine as well! Best at targeting smooth muscles = bronchio relaxation.
