BIOC39H3 Lecture Notes - Lecture 7: Major Histocompatibility Complex, B-Cell Receptor, Somatic Hypermutation
12 May 2020
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Those sites will be brought together, the rag enzyme will cleave that. Dna and then there will be repair mechanisms that will join those 2 segments together: the coding joint will have p (palindromic) and n(non-templated) nucleotides like bcr. : heterodimer associates with 4 invariant membrane proteins for cell surface expression. The delta chain locus is within the alpha chain locus on the chromosome 14, between the v genes segments and the j gene segments. There have few v, d, j gene segments highly reduced compared to the alpha chain locus. The gamma chain locus is on chromosome 7, only some gene segments. But two d segments can be incorporated in final gene sequence. Increases the potential number of gene segment combinations. Increased junctional diversity- p/n nucleotides at dd, vd, and dj junctions. Two classes of : t cells: cd8 cytotoxic t cells. 4: express co-receptor cd8- recognizes a conserved site on.
