BIO315H5 Lecture Notes - Lecture 5: Neuron, Peptide, Clathrin
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What are the kinds of exocytosis: constitutive, regulated. It is involved in the regular secretion of molecules that is performed by all cells. It operates continuously and uses a default pathway that is straightforward in unpolarized cells and more complex in polarized cells. It uses the clathrin coated class of transport vesicles. Explain figure 13. 63: the three best understood pathways of protein sorting in the trans-golgi network. It is a secondary pathway that is commonly used in specialized cells for secreting like hormones, neurotransmitters, digestive enzymes etc. In this pathway, substances are initially stored in secretory vesicles for later release. They release rapidly, on demand and upon signal detection. Explain figure 13. 62: the constitutive and regulated secretory pathways. There is selective aggregation of secretory proteins in the golgi. It is unlikely that each binds to a receptor and might be more similar to autophagy (natural, regulated destructive mechanism of the cell that disassembles unnecessary or dysfunctional components.
