BIO315H5 Lecture Notes - Lecture 4: Cytosol, Threonine, Sh2 Domain
Document Summary
It binds to four calcium molecules, two on each end: when calcium binds, it leads to a conformational change that make the dumbbell shape fold upon itself and allows it to interact with other proteins. It is made of twelve subunits; six rings sit on top of each other: each subunit has a subunit made of two domains. It is possible for all twelve domains to be activate within the kinase: there are calcium dependent oscillations, in which activity increases, once the calcium levels drop, the cycle begins again. In high frequency calcium oscillations, the spikes and activity continues to increase until the kinase is calcium independent. With olfaction, the sense of small is dependent on gpcrs: each olfactory neuron has a specific smell and gpcr that it can recognize. The photoreceptor cell can release neurotransmitters to another cell: rhodopsin kinase (grk 1); there are seven of them.
