BIO310H5 Lecture Notes - Lecture 4: Axon Hillock, Gap Junction, Neurotransmission
Document Summary
Bio310 lecture 4 - the synapse: neurotransmission and pharmacology. Resting membrane potential -70mv: soma only has a graded potential. If strong enough to open na channels ap is generated. Na channels are where axon hillock joins soma (voltage gated) when open influx na: spike initiation zone, ap is generated in axon hillock/ spike initiation zone, ap propagates through axon and reaches terminal, touch receptor. Na channels open graded potential na channels ap graded ( post synaptic neuron) if enough ap ( moves from one neuron to the next: grade potentials are produced in the soma. Axon terminals: many divisions: one neuron can communicate with many other neurons (network, many synaptic nodes can be on one cell. Gap: synaptic cleft (between post and presynaptic membrane) Vesicles are covered with lipid bilayer: can fuse with the cell membrane to excrete neurotransmitters inside them.
