BIO310H5 Lecture Notes - Lecture 12: Distal Convoluted Tubule, Proximal Tubule, Membrane Transport Protein
Document Summary
Tubular secretion opposite or reabsorption occurs at distal tubules and. Kidney plays very important role wrt irons and most important acid/base balance. Anything will be secreted to the tubules from the blood. Organic anions need to be secreted; they need to eventually be eliminated. There are no channels to directly remove organic anion from blood to filtrate. Cell takes advantage of sodium potassium pump, because a sodium gradient is established (more na+ outside of cell). Sodium follows it"s gradient along with di and tricarboxylates. The ates will be exchanged with inorganic anions. Organic anions within the cell can now be exchanged via symporter systems. Endogenous body will use ex; camp, prostaglandin they"ll be secreted by indirect usage of sodium. We don"t have carrier proteins for penicillin alone. There will be a day, so, you"d need to you have to decrease the dose of penicillin because you know the penicillin will last longer bc of the competition and delay.
