BIO304H5 Lecture Notes - Lecture 5: Ouabain, Atp Hydrolysis, Ion Transporter
Document Summary
Sodium potassium pump (discovered by skou) we need replenishment of these ions because they leave via leak channels, transporters and ion channels. Ion pumps use energy via hydrolysis of atp and pump ions against concentration gradient (active transport) Important for maintaining na and k gradients (pumps 3 na out of cell for every 2 k) It"s a p type atpase (large family of proteins that do active transport by atp hydrolysis) Atp hydrolysis chemical e is stored in bonds in atp and is released. It has a dimeric structure (made of similar subunits 1 alpha, 1 beta) It"s in plasma membrane that pumps na out of cell and k in cell against concentration gradients. Cells have lots of k and low na interdependent. Cells keep low na and high k, then pump moves 3 na out and moves 2 k in, so it removes 1 positive. It helps maintain resting potential charge from intracellular space)
