BIO206H5 Lecture Notes - Lecture 5: Gene Expression, Exon, Uracil
Document Summary
Adjacent h bonds in parallel and distorted ones in anti-parallel. The variety of b sheets that contribute to 3ary structure of protein. Interior is formed by a number of parallel and anti-parallel b sheets. There"s a tendency of amino acids to be grouped together; this is what drives the initial folding of proteins to their 3ary structure. There will also be other ways in which proteins fold: A single globular protein could have 1 domain, or two lobes to it (two domains). Domains area subunit if it"s a 3ary structure that folds independent of one another. Ex; a very common one is a helix-turn-helix-motif; involves two 2ary structure elements and a turn; the function of the turn within this motif is to coordinate divalent calcium ion. Once we identify a function of 1 domain, we can extrapolate to determine what other domains do. 4ary structure: much of the biological activity comes from various polypeptides acting with other polypeptides.
