BIO202H5 Lecture Notes - Lecture 9: Beta Adrenergic Receptor Kinase, Circadian Clock, Circadian Rhythm
Document Summary
A ligand gated receptor associated with g protein. Signalling molecule, receptor triggers activation of a subunit (alpha subunit) to exchange gtp for gdp. Alpha subunit dissociates from the b (beta) and r (gamma) subunits and triggers a cellular response. This triggers a secondary messenger (camp) and amplifies a signal. Would not be able to pass through the phospholipid bilayer. ____________ hormones bind to a receptor _______ the cell and alter. Only, hydrophobic hormones alter transcription of dna. Internal control and entrainable cycle for 24 hours. Entrainable the cycle in body matches to the environment. Grk2 helps regulate the pace of circadian rhythm and its response to environmental cues. Grk2 functionality interacts with the molecular clock. Synchronization of onset of migration and season changes are key to success. Decreases in light before migration to south circadian clock genes cause insulin-like peptide decrease. This results in decrease in juvenile hormone (jh) The target tissues (gonads) reduce reproductive hormones.
