BIO200H5 Lecture Notes - Lecture 14: Tyrosine Kinase, Imatinib, Fusion Protein
Document Summary
Slide 4: do(cid:374)"t ha(cid:448)e to (cid:373)e(cid:373)orize these types of cells, this is a fusion protein that happens between the chromosomes. It is an enzyme that is enough to activate. Sh3 is mandatory: tyrosine kinase is a receptor. Slide 6: there will be truncation and rearrangement, because the pieces of the chromosome, these 2 genes are going to be fused together under one promoter. In order to reduce the number of cell cycles, to inhibit the cell cycles. Slide 7: this atp site, this drug which is gleevec will allosterically inhibit. It will bind to a place which prevents atp from accessing the domain: allosteric inhibition, binds to hide binding site, competitive inhibitor, binds to same binding site. Slide 8: after years of treatment, the patients that were very responsive to the drug started to develop a resistance, how did they develop this resistance, does(cid:374)"t happe(cid:374) to all of the patie(cid:374)ts. Its susceptibility to develop this kind of mutation.
