BIO200H5 Lecture Notes - Lecture 11: Nonsteroidal Anti-Inflammatory Drug, Ion, Protein Isoform
Document Summary
Drug with first-pass effect - most likely found in cardiovascular. Drug with cumulative effect - treated over time with long-lasting effect. Target concentrations - met by maintenance dose. Foreign molecules that enter the body = . Drugs/chemicals that enter the body are (eventually) eliminated. There are 2 fates a drug can have; Roundabout elimination where they first get metabolized. Plasma undergoes metabolism in phase i, ii, drug metabolite phase and eventually forming inactive drug metabolites which are transformed in order to enhance excretion of the drug. Allows us to minimize substances that could potentially be harmful for our health. All tissues = some ability to metabolize drugs. Liver is powerhouse of metabolism in the body. = enhance drug elimination and decrease drug half-life turn it into something polar that is easily eliminated or more after it was taken. Transform it into a composition that is more easily eliminated from the body - Prevents toxic accumulation of drug in body.
